Grup Riset/Research Group:
Biomateri Hewan (Animal Biomaterial)
Minat Penelitian/Research Interest
We use primary cell culture and in vivo analysis to study developmental stages of airway epithelial cells, especially their highly organized multiciliated cells. The organization of airway epithelial cells has pivotal role for respiratory health, and defects in their structure, coordination, and polarization have recently been found to underlie diverse of human disease. Using live-cell imaging and loss of function analyses, our goal is to understand dynamics of functional multiciliated cells and its role in the pathology of respiratory disease.
Riset Terkini/ Recent Project
Role of planar cell polarity signaling in airway epithelial homeostasis (collaboration with Osaka University, Japan).
(Publikasi Terpilih) Selected Publication
Herawati E, Taniguchi D, Kanoh H, Tateishi K, Ishihara S, Tsukita S. Multiciliated basal body align in stereotypical pattern coordinated by apical cytoskeleton. J Cell Biol. 2016 Aug 29;214(5), 571-86.
Herawati E, Taniguchi D, Kanoh H,Tateishi K, Ishihara S, Tsukita S. Basal bodies of airway multiciliated cells align in stereotypical pattern coordinated by the apical cytoskeleton. Poster presentation. The 68th Annual Meeting of the Cell Biology Society of Japan. Kyoto, Japan. June 15-17, 2016.
Herawati E, Taniguchi D, Kanoh H, Tateishi K, Ishihara S, Tsukita, S. Coordination of basal body orientation in differentiating multiciliated cells: Mechanism revealed by long-term live imaging. Invited speaker for workshop. The 38th Annual Meeting of the Molecular Biology Society of Japan. Kobe, Japan. December 1-4, 2016.
Herawati E, Taniguchi D, Kanoh H, Tateishi K, Nishida T, Ishihara S, Tsukita, S. Analysis of the dynamic behavior of basal bodies in tracheal multiciliated cells. Poster presentation. The 2015 ASCB/IFCB Annual Meeting. San Diego, USA. December 12-16, 2015.
Herawati E, Tanaka H, Tateishi K, Tamura A, Tsukita, S. Loss of occludin caused mucociliary defect with reduced number of multiciliated cells in mouse. Poster presentation. The 2014 ASCB/IFCB Annual Meeting. Philadelphia, USA. December 6-10, 2014.
Kitani S, Miyamoto, KT, Takamatsu S, Herawati E, Iguchi H., Nishitomi K, Uchida M, Nagamitsu T, Omura S, Ikeda H, Nihira T. Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. Proc Natl Acad Sci USA. 2011 Sep 27; 108(39):16410-5.